Piccadilly Pub is a chain of casual dining restaurants located in the US state of Massachusetts. The first Piccadilly Pub restaurant was opened by William C. Martin in 1973 in the town of Westborough, Massachusetts.

The chain offers a menu of American cuisine, with particular emphasis on seafood such as fish and chips, New England clam chowder, fried clams, lobster, scallops, and shrimp. It also claims to be "famous" for its boneless buffalo wings.