The San Francisco Zoo is a 100-acre (40 ha) zoo located in the southwestern corner of San Francisco, California, between Lake Merced and the Pacific Ocean along the Great Highway. The zoo's main entrance, once located on the north side across Sloat Boulevard and one block south of the Muni Metro L Taraval line, is now to the west on the ocean side of the zoo off of the Great Highway.

This zoo is the birthplace of Koko the gorilla, and housed 693 individual animals representing about 197 species as of 2011.