Montepulciano d’Abruzzo is one of Italy's most famous wines, and can be found on wine store shelves all around the world. This classic, well-rounded, plum-scented Italian red is made from Montepulciano grapes grown in the Abruzzo region, on Italy's Adriatic coast. It is quite distinct from Vino Nobile di Montepulciano, which is a Sangiovese-based wine from Tuscany.