Trejo is known for his distinctive appearance. In addition to his heavily lined face (usually sporting a long mustache), he has displayed the large tattoo on his chest for many roles (the tattoo depicts a woman wearing a sombrero). He often plays thugs or lowlife characters, although he has also played sympathetic characters in films such as Robert Rodriguez's Spy Kids trilogy, Bubble Boy and a guest appearance on the USA Network series Monk where art imitated life in his portrayal of a convict roommate to Tony Shalhoub's undercover detective. He also appeared in a Season 2 episode of Desperate Housewives, where, as another good-guy character, he was sent by Carlos to help Gabrielle deal with her grief of losing her unborn baby. He voiced the character Enrique on King of the Hill, and Octavio's character on that show is based on his appearance. His role on King of the Hill was referred to in the HBO series Unscripted where he had a cameo appearance. He also is featured in an episode ofTim and Eric Awesome Show, Great Job! and an episode of Do IT LIVE with actors Anna Bennett and Claudia Pickering, shot in Downtown Los Angeles, by the name of Sebring feat. Danny Trejo. He also made guest appearances in the award-winning series Breaking Bad in 2009 and 2010.