Guidugli played collegiately at the University of Cincinnati from 2001 to 2004. He owns most of the school’s passing and total offense records. He is ranked 29th for all time yards and offense of all NCAA division I A FBS schools by a quarterback.  He finished his career with 11,453 yards on 880 of 1556 passes (56.6%) and 78 touchdowns. He also rushed for 208 yards and scored five times on 235 carries.

He was signed by the Tennessee Titans as an undrafted free agent in 2005.  He also played in the Canadian Football League and the Arena Football League.  Currently Guidugli is the offensive coordinator and quarterbacks coach for Central Michigan University.